The themes of portions of Isaiah 40 and 41 are:  God is in control and He tells us what He's going to do through His prophets.  There are many layered prophecies there as well.

Paganism flourishes during the reign of Manasseh. In today’s reading, Isaiah turns the focus beyond the godless era and toward the restoration of God’s people, physical restoration and spiritual restoration.  

One thing we observed during this reading is that prayers are answered and requests to God are honored. However, if the prayer or request is outside the will of God, there are often dire consequences. Think about when the people asked for a king. Samuel knew that the people should not have a king, and warned the people of such. They, however, demanded a king. So what happened? God gave them a king. Now they are suffering the consequences for that request. Hezekiah bargained for longer life. God granted that request and dire consequences ensued. As a result of the 15 year extension, was the birth of Manasseh, who took the throne at age 12, one of the most evil of all of Judah’s kings. 

 If you haven’t read Isaiah 40 in a while, please read it again today! And while you’re at it, read Job chapters 38-42. It will give you a fresh perspective on just how great God is! And then read this

Isaiah 41:10
So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.

This great God who laid the earth’s foundations, gives orders to the morning, sends lightning bolts on their way, knows when the mountain goats give birth, commands the soaring of the eagles, etc, etc, etc…cares enough about each of us to strengthen and help us. And in addition to that, "He gathers the lambs in his arms and carries them close to his heart..."  (Isaiah 40:11)  What an amazing God we have!